Dihydropteroate synthase (DHPS) is a crucial enzyme in the folate biosynthetic pathway, catalysing the formation of essential folate cofactors that underpin DNA synthesis and cellular functioning.

NUDT5 enzyme acts as a molecular scaffold that maintains metabolic balance. Inside every cell, a finely tuned metabolic network determines when to build, recycle or stop producing essential molecules.

Although they number from 1 (thiamine) to 12 (cobalamin), there are eight B vitamins—don't bother seeking numbers 4, 8, 10, or 11. The rest are all facilitators of the nervous system and tend to work ...

While most enzymatic activity is conducted through chemical binding interactions between molecules, in some cases, the mere presence of an enzyme can affect intracellular functions. While exploring ...

DNA is the raw material of modern medicine yet is the only part of drug development not accessible at the lab bench. DNA synthesis, the first step in most biological workflows including gene synthesis ...

This review synthesizes current knowledge on the intricate metabolic interplay between folate and biopterin cofactors, emphasizing their structural similarities, shared enzymatic pathways, and ...

Folic acid, also known as vitamin B9, is an important B-vitamin with many vital functions in the human body. It was ...