A publication from Acta Pharmaceutica Sinica B discusses the structure-based development of potent and selective type-II kinase inhibitors of RIPK1. Receptor-interacting serine/threonine-protein ...
Researchers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to explore kinase-substrate interactions in human cellular systems. These ...
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A short-lived kinase state that's essential for normal cell migration and T-cell function
Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows the kinase to repeatedly modify its ...
Researchers from Vertex Pharmaceuticals Incorporated have solved the three-dimensional atomic structure of glycogen synthase kinase 3 beta (GSK3), an enzyme involved in the regulation of blood glucose ...
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