The promyelocytic leukemia (PML) tumor suppressor is essential for the formation of PML nuclear bodies (NBs). PML and PML-NBs have been implicated in the regulation of growth inhibition, senescence ...
NBs are nuclear matrix-associated structures of unknown function that contain a number of proteins, including PML, SP100, ISG20, PIC1/SUMO-1, LYSP100, PLZF, INT6, CBP, RB1, RFP and ribosomal protein P ...
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