PTIR calculates the rates at which originally monomeric proteins are transformed into aggregates at various temperatures under initial-rate settings. Utilizing SMSLS for identical conditions generates ...

Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail.

By Vijay Kumar Malesu New mouse data reveal that ageing neurons struggle to clear synaptic proteins, shifting the burden to ...

Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis (ALS) affect ...

The formation of aggregates due to protein misfolding and resulting protein instability is associated with several diseases. Previous studies have shown the potential of sulfobetaine polymer, a ...

Researchers have used computational models to understand what drives the accumulation of alpha-synuclein protein, a key culprit in the development of Parkinson’s disease. The study, published today as ...

Researchers headed by a team at the Centre for Genomic Regulation, Barcelona Institute of Science and Technology and at the Wellcome Sanger Institute have developed an AI tool that they say has made a ...

Proteins form the building blocks of life, but when they form unusual clumps inside the brain, they raise an alarm that ...

Northwestern Medicine scientists have zeroed in on a cellular gatekeeper that may hold promise for treating abnormal protein ...

Explore why tau still lacks treatments despite its critical role in Alzheimer's disease and other tauopathies.