Ahmet Coskun's lab has developed iseqPLA to map protein interactions. An artistic rendering of sub-cellular activity: The cell membrane is seen at the top, nucleus on the bottom/right. Protein pairs ...

The dementia associated Tau protein — known for its role in microtubule regulation — has now been found to also play important roles in the nerve signaling and mitochondrial function in the brain. A ...

A group of international researchers reports the availability of a new “map”’ of every gene, protein, and metabolic pathway required for a cell to efficiently secrete recombinant proteins. The team, ...

The decline of brain endothelial cell (BEC) function, due to aging, is a contributor to neurological disease. BECs lining the inner walls of blood vessels regulate the exchange of molecules across the ...

Researchers have conducted the most comprehensive analysis to date linking plasma proteins to genetic variation in individuals from continental ...

Misfolded proteins can appear as small aggregates, soluble monomers, or large insoluble inclusion bodies. While the fundamental biophysical mechanisms that cause cytotoxicity are not fully understood, ...

Drug development and production rely on stringent quality controls, reproducibility, and verification. Biopharmaceuticals, including protein-based therapies, require extensive characterization, ...

Scientists have unearthed surprising details about how our bodies handle insulin – the hormone that plays a crucial role in regulating blood sugar and developing diabetes. The discovery could lead to ...

Tissues are where most biological functions, drug effects and diseases occur, and are often considered a homogenous entity where different types of cells are woven in regularly repeated patterns.

For the neurons in the brain to work smoothly and be able to process information, the central nervous system needs a strictly regulated environment. This is maintained by the blood-brain barrier, ...