CWRU has a decades-long history of research into pyruvate dehydrogenase complex deficiency (PDCD). The pyruvate dehydrogenase complex (PDC) is a multiple enzyme complex in the shape of a pentagonal ...

FDA grants a Type A meeting on December 18th to review new and expanded datasets submitted by Saol to help identify a feasible path forward without the need for an additional clinical trial ROSWELL, ...

March 18, 2024 – Cure Mito Foundation and Hope for PDCD foundation, both patient-led foundations focused on advancing research and supporting families affected by Leigh syndrome and Pyruvate ...

The dehydrogenase complexes serve as pivotal regulators in cellular metabolism, orchestrating key oxidative reactions within the tricarboxylic acid (TCA) cycle and beyond. These multi‐enzyme ...

The U.S. FDA issued a complete response letter (CRL) for the NDA to privately held Saol Therapeutics Inc.’s rare disease treatment, sodium dichloroacetate (SL-1009), for pyruvate dehydrogenase complex ...

GRAND RAPIDS, Mich. — A West Michigan family is spreading the word about their daughter's rare diagnosis in the hopes of funding research about Pyruvate Dehydrogenase Complex Deficiency (PDCD). Andrew ...

Cancer cells are known to favor aerobic glycolysis for energy production, a phenomenon termed the Warburg effect. This metabolic shift is essential for tumor growth, supplying energy, metabolites, and ...

Cure Mito Foundation and Hope for PDCD Foundation, both patient-led foundations focused on advancing research and supporting families affected by Leigh syndrome and Pyruvate Dehydrogenase Complex ...