DNA replication is a complex process with many moving parts. In baker's yeast, the molecular complex Ctf18-RFC keeps parts of the replication machinery from falling off the DNA strand. Human cells use ...

DNA replication is a tightly controlled process that copies the genetic code, allowing its instructions to be conveyed from one generation of cells to the next. In diseases like cancer, these ...

During replication, DNA polymerases are positioned on each strand of DNA . Using a microscope slide as an anchor, we tethered DNA to a bead and stretched it with a flow of solution. We tracked how the ...

Half a century ago, scientists Jim Watson and Alexey Olovnikov independently realized that there was a problem with how our DNA gets copied. A quirk of linear DNA replication dictated that telomeres ...

MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...

A new study has illuminated an important process that occurs during cell division and is a likely source of DNA damage under some circumstances, including cancer. A new study from scientists at the ...

DNA, or deoxyribonucleic acid, is the hereditary material found in nearly all living organisms. It carries the genetic instructions for the development, functioning, growth, and reproduction of all ...

In recent months I’ve highlighted two excellent iPad apps by OnScreen Science that center around a 3D model of DNA. For the sake of completeness, let me now mention the third and final member of the ...

To establish chronic disease, the hepatitis B virus (HBV) must have its genome of relaxed circular DNA (rcDNA) turned into covalently closed circular DNA (cccDNA). Exactly how rcDNA becomes cccDNA has ...

Researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer. Every day, billions of cells in your body ...