It is the first thing you need to fix the issue as stated above. For that, you need to run the virtual machine showing the error and go to the Devices > Install Guest ...
The "Bootable" legacy ISO you've used is in fact not bootable, it relies on CDROM emulation provided by BIOS. VMs don't usually do this sort of emulation. If you set the guest OS to something like ...
Installing the Extension Pack via GUI. How to Enable USB in VirtualBox Your email has been sent If your data center relies on VirtualBox and your virtual machines ...