Ribbon structure of the BRCA2 protein. Mutations in the BRCA2 gene are linked to increased risk of breast cancer. New work from UC Davis shows how individual BRCA2 proteins work to repair damaged DNA, ...

Akeega combines niraparib, a PARP inhibitor, and abiraterone acetate, a CYP17 inhibitor, into a single tablet for BRCA2-mutated mCSPC.

Zoe Wilson thought she may be at risk. It wasn’t just a vague gut feeling: the risk was demonstrable and clear, running ...

The study showed that oxidative stress, which is considered to contribute to cancer development, actually suppressed cancer in rats with BRCA2 gene mutations. Oxidative stress is considered to ...

Although genetic mutations in BRCA1 or BRCA2 are associated with a younger onset of breast and ovarian cancer, women with these genetic mutations continue to face a high risk of cancer incidence after ...

A BRCA2 gene mutation is most often associated with breast cancer, but it can also raise the risk of other types of cancer. Two years after Michele Miller, 53, was diagnosed with breast cancer, she ...

New study shows that in women with BRCA1 or BRCA2 mutations, their breast cells already carry a clear pattern of DNA “damage ...

Please provide your email address to receive an email when new articles are posted on . Researchers assigned clinical classifications to thousands of BRCA2 variants of uncertain significance. Research ...

"There remains an urgent need for novel therapies for patients with BRCA2-mutated mCSPC, who face significantly faster disease progression and often shorter survival compared to those without the ...